NEIL Harris could stick with the same side that started in the victory over Port Vale on Tuesday night.
Byron Webster replaced Sid Nelson at Vale Park and was outstanding alongside Mark Beevers in the centre of Millwall's defence.
The pair should continue their partnership if Nelson doesn't recover from a rib injury.
Left-back Joe Martin was on the bench for the first time this season this week but will find it difficult to break into a defence that has kept three clean sheets in the last five games.
Harris has brought on Shane Ferguson for Fred Onyedinma in each of the last two games and the Northern Ireland international could be pushing for a starting spot on Saturday.
Southend dropped into the relegation places after losing 1-0 at home to Shrewsbury last weekend, but they haven't lost away in the league since a 3-1 defeat at Morecambe in League Two in May, drawing all four games since then.
That record will be tested this weekend as there are doubts surrounding four of their players.
Phil Brown doesn't expect winger Stephen McLaughlin to be fit, while strikers Noel Hunt and David Mooney are rated 50/50.
Former Hull boss Brown will also make a late decision in relation to left-back Ben Coker.
Meanwhile midfielder Michael Timlin, who grew up near The Den and played with Neil Harris at Southend, will be forgetting about any attachment to the Lions when he aims to help his side climb out of the bottom four.
He told the Essex Echo: "We need to go back to basics, we need to work hard, cut out sloppy mistakes and be on top of our game.
"It's also going to be a special afternoon for me but any sentiment I have towards Millwall will be going out the window on Saturday."
"I'll also have loads of mates who are there just watching Millwall anyway but it's not about that for me.
"I was delighted for Neil when he got the job but they're going through a transition and it could take a season to get things right there.
"Neil's a Millwall man and he's doing all the right things. He's brought in former Millwall players David Livermore and Andy Frampton to his coaching staff and they will all be doing everything they can for the club."
Sky Bet match odds:
Millwall 6/5 Draw 23/10 Southend 23/10
Probable Millwall team:
4-4-2: Archer; Edwards, Webster, Beevers, Craig; Onyedinma, Abdou, Williams, Upson; Morison, O'Brien.