THIS is a meeting of two sides who will be desperate for three points that could put a totally different gloss on their respective starts to the season.
A win for either side would leave the other with a record of three defeats from four games and talks of an unfolding mini-crisis.
Both were also knocked out of the League Cup in the first week of the season and, though that is hardly cause for deep concern, another defeat would darken the complexion of their respective seasons.
Millwall manager Neil Harris will want to halt a run of three consecutive defeats, and he'll have to plan without both first-choice left-backs as Shane Ferguson is likely to join Joe Martin in missing this crunch fixture through injury.
That decision alone will require serious thought. Harris will have to decide whether to split the centre-back pairing of Sid Nelson and Tony Craig – which looked solid in open play against Barnsley, even if Millwall's defence of set-pieces requires some work – and recall Byron Webster with Craig slotting in at left-back.
Jimmy Abdou adds more security to the Lions midfield but Shaun Williams was withdrawn against Barnsley after a lacklustre last two games and it is his position that could be under threat with the emergence of 19-year-old Ben Thompson.
Up front Lee Gregory and Steve Morison must rediscover the scoring touch that brought them three goals in the first two games of the season.
Meanwhile, Scunthorpe boss Mark Robins was quite frank in his assessment of how his side played in the 3-0 defeat to Wigan on Wednesday night.
He said: "We were beaten by the better side. We gave them, I think, too much space and certainly too much time on the ball. We were miles off – miles off it and miles off them.
"We played against a good side, we conceded early doors another penalty and we've gifted them a goal.
"It was a disappointing night and again it's one of those that we've got to take on the chin and learn from, and learn from quickly."
It's a game after which neither manager will want to be repeating similar sentiments.
Sky Bet match odds:
Scunthorpe 7/5 Draw 23/10 Millwall 19/10
Probable Millwall team:
Forde; Cummings, Webster, Nelson, Craig; Onyedinma, Abdou, Williams, Upson; Gregory, Morison.