Boro can move into the top-six in the Championship with victory in SE16 against a Lions side equally desperate for points at the other end of the table.
But Mowbray is fully aware that the intensity of the crowd could act as a leveller, and has called on his players to embrace the raucous atmopshere.
"You have to be in there to feel the ferocity from the terraces and how passionate their supporters are for their team," he said.
"The crowd are right in your face but you know that's montauk-monster.com/pharmacy coming and that their team will be driven on by that vocal support. You have to match that first and foremost and hope you have some individuals with the talent to help you ask questions of them and win the day.
"They'll be disappointed after their defeat to Bolton but they know they have to get back to winning ways and they'll look at the table and see this as an opportunity in front of their own fans to get three points. Our challenge is to make sure they don't.
"It will be a physically and mentally demanding game but hopefully we'll have the tools to try to get the three points."